Dr. Mathews is an adult intensivist and a health services researcher in the Division of Pulmonary, Critical Care, & Sleep Medicine and Department of Emergency Medicine. She graduated from Yale University with a B.A., in History of Science, History of Medicine, and Sociology, and later with an M.D. and M.P.H. from Tufts University School of Medicine. She completed her internship and residency at Yale University School of Medicine (YSM)/Yale-New Haven Hospital, followed by a year as an Instructor in YSM Section of General Internal Medicine, serving as a clinician educator in the Yale Primary Care Clinic. Building upon quantitative training obtained in her Masters in Public Health, she completed a clinical and T32-funded research fellowship in Pulmonary, Critical Care, and Sleep Medicine at Yale. She joined the faculty at Icahn School of Medicine at Mount Sinai (ISMMS) in 2013, and was granted a K-12 scholar position in the NHLBI-funded Mount Sinai Emergency Medicine Research Career Development Program for two years. During her K12 scholar period, Dr. Mathews completed advanced research training at ISMMS with a Masters of Science in Clinical Research.

She currently serves as an advisor/consultant to the ISMMS Department of Scientific Computing and Mount Sinai Data Warehouse, collaborating with data analysts to create more dynamic tools and harness big data to address clinical research needs in emergency medicine and critical care. Dr. Mathews also serves as a co-investigator for Mount Sinai on the NHLBI Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL). Dr. Mathews is the recipient of the 2016 American Thoracic Society Foundation Unrestricted Grant in Critical Care and an NHLBI K23 mentored research career development award, examining ICU triage decisions for critically ill ED patients in respiratory distress at the ED-ICU interface, using advanced mixed methods strategies and integrating innovative tools from business and computer science in clinical research.